科學論文選讀(一)

課程介紹

How to read a scientific paper

How to read a scientific paper

Lecture: Induced pluripotent stem cells (iPSCs): derivation and applications

Application of iPSC technology in drug screening (paper reading I) Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders. Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013.

The basics for finding causative genes of human diseases

Finding the disease genes of simple diseases.(Paper reading II) Edvardson, S., Nicolae, C.M., Agrawal, P.B., Mignot, C., Payne, K., Prasad, A.N., Prasad, C., Sadler, L., Nava, C., Mullen, T.E. et al. (2017) Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood. Am J Hum Genet, 101, 267-273

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy (Introduction + Fig. 1, Fig. 2) (Paper reading III) Nature. 2016, 534, 553-557.

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy (Fig. 3, Fig. 4 + Discussion) (Paper reading IV) Nature. 2016, 534, 553-557.

Introduction on innate immunity

Alarmin and infection (paper reading V) Immunity. Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection. 2015, 42(3):566-79.

Nutrient, Lymphoid cells and Barrier functions

(Paper reading VI) Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity. Science. 2014, 343, 432-437.

Drug discovery process in pharmaceutical company (Hit to Lead optimization)

(Paper reading VII) Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIA. Journal of Medicinal Chemistry. 2015, May

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