生物有機實驗技術

Course Objective: The course includes current topics in the field of Bioorganic Chemistry via textbook reading, literature report and group discussion in English. The course is designed to reinforce the student’s abilities at subject textbook knowledge, literature reading, information digestion, verbal expression and listening comprehension.

Biotechnology Related Students

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Oral presentation (50%) + Powerpoint (30%) + Discussion (20%)

• BIOMOLECULES AND THEIR CONFORMATION

  1. Equilibria of RNA Secondary Structures. 2. Tools for Stabilization of Peptide Secondary Structures. 3. Stabilization of Peptide Microstructures by Coordination of Metal Ions.

• NON-COVALENT INTERMOLECULAR INTERACTIONS.

  4. Carbohydrate Recognition by Artificial Receptors. 5. Bioorganic Receptors for Amino Acids and Peptides: 6. Combining Rational Design with Combinatorial Chemistry.

• STUDIES IN DRUG DEVELOPMENTS.

  7. Building a Bridge Between Chemistry and Biology. 8. Inhibitors Against Human Mast Cell Tryptase. 9. Preparation of Novel Steroids by Microbiological and Combinatorial Chemistry.

• STUDIES IN DIAGNOSTIC DEVELOPMENTS.

  10. Selectivity of DNA Replication. 11. Exploring the Capabilities of Nucleic Acid Polymerases by Use of Directed Evolution. 12. Labeling of Fusion Proteins with Small Molecules.in vito.

• CATALYSIS.

  13. Protease-catalyzed Formation of C–N Bonds. 14. Twin Ribozymes. 15. RNA as a Catalysts: The Diels—Alderase Ribozyme.

Highlights in Bioorganic Chemistry: Methods and Applications, 2004 Carsten Schmuck (Editor), Helma Wennemers (Editor), Ronald Breslow Reference Book(s) and Journals: Biotransformation in Organic Chemistry; K. Faber, 2000 Molecular Biology; R. Weaver, 2005 Angew. Chem. Int. Ed. J. Am. Chem. Soc. Org. Lett. ChemBioChem Chem. Comm. J. Biol. Chem. Biochemistry. Biochemical J.

地點

竹銘館208室

時間

Mon. GH

聯絡方式

Ext. 56979