有機金屬於有機及高分子合成之應用
Orgarometallic for Organic and Polymer Synthesis
| 節 | 週二 |
|---|---|
2 09:00–09:50 | 有機金屬於有機及高分子合成之應用 SB203（光復） 3 節連堂 |
3 10:10–11:00 | |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
利用過渡金屬進行催化反應,生成新的碳碳鍵,是近年來最為強大的合成方法,在有機合成中已佔有舉足輕重的角色,本課程將會探討基本金屬的鍵結與配位性質,催化過程的反應機構,以及各種不同金屬的催化反應應用於各式有機合成之官能基的轉換以及高分子之合成。 Using transition-metal catalyzed reactions to proceed carbon-carbon formation is the most powerful tool and plays an important role in modern organic synthesis. This course will discuss the fundamentals of bonding and coordination properties, cataylic mechanisms, and a variety of transition metals applied in useful functional group transformations. Organometallics towards polymer synthesis will be also discussed.
大二有機化學 Before you take this course, please make sure you have passed sophomore organic chemistry.
無備註
板書及投影片教學 I will mostly use chalk and black board. Sildes are sometimes auxiliary.
評分方式:期中考(50%)、期末考(50%) Grading: Midterm (50%) and Final (50%)
The Basic Chemistry of Organopalladium Compounds
Formalisms, Electron Counting and Bonding
Classification of the Reactions Involving Pd (II) Compounds and Pd (0)
Stoichiometric and Catalytic Reactions
Organometallic Reaction Mechanisms
Oxidation Addition Reductive Elimination Transmetallation Migratory Insertion
Oxidative Reactions with Pd (II) Compounds
Wacker-Type Reactions and its Applications.
Catalytic Reactions with Pd (0) and Pd (II)
Suzuki, Still, Heck, Sonogashira, Negishi, Kumada, and Hartwig Coupling Reaction.
Synthetic Applications of pi-Allyl Transition Metal Complexes
Palladium-Catalyzed Tsuji-Trost Allylations
Olefin Metathesis
Mechanism Investigation Ring-Opening Metathesis Polymerization
Palladium-Catalyzed C-H Activation Reactions
Recent Progress on Pd-Catalyzed C-H Activation
| 週次 | 主題 |
|---|---|
| 第 1 週 | Formalisms, Electron Counting and Bonding 9/16 |
| 第 2 週 | Basic Organometallic Reaction Mechanisms 9/23 |
| 第 3 週 | The Basic Chemistry of Organopalladium Compounds and Classification of the Reactions Involving Pd (II) Compounds and Pd (0) Complexes 9/30 |
| 第 4 週 | Oxdiative Reactions with Pd (II) Compounds: Wacker Process 10/7 |
| 第 5 週 | Oxdiative Reactions with Pd (II) Compounds: Wacker-type Reactions with other Nucleophilies 10/14 |
| 第 6 週 | Catalytic Reactions with Pd (0) and Pd (II): Suzuki Coupling Reactions 10/21 |
| 第 7 週 | Catalytic Reactions with Pd (0) and Pd (II): Stille Coupling Reactions 10/28 |
| 第 8 週 | Catalytic Reactions with Pd (0) and Pd (II): Buchwald-Hartwig Aminations 11/4 |
| 第 9 週 | Catalytic Reactions with Pd (0) and Pd (II): Heck Coupling Reactions and Sonogashira Coupling Reactions 11/11 |
| 第 10 週 | Midterm Exam 11/18 |
| 第 11 週 | Negishi Coupling Reactions and Nickel-Catalyzed Kumada-Corriu Coupling Reactions for Living Polycondensation 11/25 |
| 第 12 週 | Palladium-Catalyzed Tsuji-Trost Allylations 12/2 |
| 第 13 週 | Ullmann Coupling Reactions and Cobolt-Catalyzed Reactions 12/9 |
| 第 14 週 | Fischer Carbene and Chromium-Catalyzed Reactions 12/16 12/16 |
| 第 15 週 | Olefin Metathesis I 12/23 |
| 第 16 週 | Olefin Metathesis II 12/30 |
| 第 17 週 | Palladium Catalyzed C-H Activation Reactions 1/6 |
| 第 18 週 | Final Exam 1/13 |
Transition Metals in The Synthesis of Complex Organic Molecules, L. S. Hegedus, University Science Books, 1994 Palladium Reagents and Catalysts: Innovations in Organic Synthesis, Jiro Tsuji, Wiley, 1994
- 地點
- 田家炳大樓715室 My office is at Tin Ka-Ping building, room 715
- 時間
- 每週二 10:00-12:00 Discussion time with me: Every Tuesday morning 10:00-12:00
- 聯絡方式
- yjcheng@mail.nctu.edu.tw