蛋白質物理生化學
Physical Biochemistry of Protein
| 節 | 週三 |
|---|---|
2 09:00–09:50 | 蛋白質物理生化學 BI308（博愛） 3 節連堂 |
3 10:10–11:00 | |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
使學生對蛋白質之生物物理化學機制有所認知與徹底瞭解
建議需具備普通物理與普通化學以上之修課經驗與能力
無備註
教師未提供此項資料
出席率: 20% 作業部份:30% 期末報告: 50%
1. Introduction of protein 2. Elementary interactions in and around proteins 3. Secondary structure of polypeptide chains 4. Protein structures 5. Cooperation transitions in protein molecules 6. Prediction and design of protein structure. 7. Physical background of protein functions
同左
- 講授：
- 70%
- 其他：
- 討論 30%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction of protein: Main functions of proteins 第一週 |
| 第 2 週 | Elementary interactions in and around proteins a. Stereochemistry of L- amino acids b. Covalent bonds and angles between them c. Vibration, rotation around the covalent bonds d. Van de Waals interaction 第二週 |
| 第 3 週 | Elementary interactions in and around proteins e. Influence of water environment f. Hydrogen bonds and their electrostatic origin g. Elements of thermodynamics h. Water-accessible surface of protein i. Influence of aqueous environment on electrostatic interactions 第三週 |
| 第 4 週 | Secondary structure of polypeptide chains a. Elementary of statistical mechanics b. Temperature and probability of states with different energy c. The first order phase transitions 第四週 |
| 第 5 週 | Secondary structure of polypeptide chains d. The theory of reaction rates e. Zipper model of alpha-helices f. beta-structure stability in water g. Properties of amino acid side chains 第五週 |
| 第 6 週 | Protein structures a. Fibrous proteins and their functions b. Membrane proteins and their and their functions 第六週 |
| 第 7 週 | Protein structures c. Globular proteins and their and their functions d. Intrinsic disorder proteins and their functions 第七週 |
| 第 8 週 | Protein structures e. Classification of protein folds f. Selection rule of protein structure 第八週 |
| 第 9 週 | Cooperation transitions in protein molecules a. Cooperative transitions b. Protein denaturation 第九週 |
| 第 10 週 | Cooperation transitions in protein molecules c. Protein folding d. Protein aggregation 第十週 |
| 第 11 週 | Prediction and design of protein structure a. Secondary structure prediction 第十一週 |
| 第 12 週 | Prediction and design of protein structure b. Tertiary structure prediction 第十二週 |
| 第 13 週 | Physical background of protein functions a. Structure function relationship of proteins 第十三週 |
| 第 14 週 | Physical background of protein functions b. Combination of elementary protein functions and flexibility of its structure 第十四週 |
| 第 15 週 | Special topics report, presentation and discussion 第十五週 |
| 第 16 週 | Special topics report, presentation and discussion 第十六週 |
| 第 17 週 | Special topics report, presentation and discussion 第十七週 |
| 第 18 週 | 期末考 第十八週 |
Protein physics: A course of Lectures. Authors: Alexei V Finkelstein and Oleg B Ptitsyn Academic Press 2002
- 地點
- 生科實驗二館203室
- 時間
- 每星期二早上9:00~12:00
- 聯絡方式
- ext 31633