基礎生物資訊統計學

09/16(Wed) Descriptive Statistics, Genomic Data Analysis (1)Introduction to statistics (2)Descriptive statistics (3)Fundamental of molecular biology (4)Genomic data analysis Lecturers:Dr. Chen-Hsiang Yeang

09/17(Thu) Probability (1)Applications in statistical genetics (2)Combinatorial analysis (3)Axioms of probabilities (4)Conditional probability and independence (5)Random variable and distribution function Lecturers:Dr. Hsin-Chou Yang

09/24(Thu) Discrete Distributions and Contingency Tables (1)An application in pharmacogenetic study (2)Discrete/continuous/mixed distributions (3)Joint/marginal/conditional distributions (4)Special discrete distributions (5)Introduction to contingency table Lecturers:Dr. Hsin-Chou Yang

Continuous Distributions, Expectations and Basic Statistics (1)Continuous random variable (2)Expectation (3)Basic statistics (4)Limit theorems (optional) Lecturers:Dr. Hsin-Chou Yang

Parameter Estimation and Confidence Interval (1)Unbiasedness (2)Point estimation (substitution principles, least square estimate, maximum likelihood estimate) (3)Interval estimation Lecturers:Dr. Shinsheng Yuan

Hypothesis Testing, P-value and False Discovery Rate (1)Hypothesis testing (2)Type I error and type II error (3)P-value (4)One-sample and two-sample z-tests (5)One-sample, two-sample, and paired t-tests (6)Bonferroni adjustment, false discovery rate, and q value Lecturers:Dr. Grace Shieh

Analysis of Categorical Data, Chisq and Multinomial (1)Incidence proportion and odds ratio (2)Two-sample test for binomial proportions (3)Contingency-table approach (4)Fisher’s exact test (5)McNemar’s test (6)Kappa statistic Lecturers:Dr. Hsuan-Yu Chen

Review Week (no class)

Midterm Exam

Correlation, Regression Analysis and ANOVA (1)Linear regression with one independent variable (2)Inference in regression analysis Lecturers:Dr. Grace Shieh (3)Diagnostic and remedial measures (4)Simultaneous inferences and other topics (5)Matrix approach to simple linear regression (6)Multiple linear regression (7)Building the regression model (8)Qualitative predictor variables (9)Analysis of variance

11/25(Wed) Logistic Regression and Statistical Meta Analysis (1)Logistic regression (2)Meta analysis (effect size, precision, study weights, summary effect, heterogeneity, fixed-effect model, random-effect model, software) Lecturers:Dr. Shinsheng Yuan

11/26(Thu) Survival Data Analysis (1)Mantel-Haenszel test (2)Survival and hazard functions (3)Kaplan Meier estimate (4)Log-rank test (5)Proportional-hazards model (6)Lung cancer study Lecturers:Dr. Hsuan-Yu Chen

12/02(Wed) Clustering (1)Clustering by geometry (K-means, EM algorithm, hierarchical clustering, self- organizing map, principal component analysis, independent component analysis) (2)Clustering on graphs (Basic concepts, max flow – min cut, normal cuts, spectral clustering, and community detection) (3)Advanced topics (Chinese restaurant process and affinity propagation) Lecturers:Dr. Chen-Hsiang Yeang

12/03(Thu) Classification (1)Binary classifications (Bayesian detection theory, naive Bayes and other generative models, non-parametric methods, Fisher linear discriminant, support vector machines and kernel techniques, artificial neural networks, and boosting) (2)Advanced topics in supervised learning (multi-class classification, feature selection, semi-supervised learning, active learning) Lecturers:Dr. Chen-Hsiang Yeang

12/10(Thu) Nonparametric Statistics (I) (1)Bootstrap (2)One-sample sign test (3)One-sample Wilcoxon signed-rank test (4)Wilcoxon rank-sum test (Mann-Whitney U test) (5)Sign test for paired data (6)Wilcoxon signed-rank test for paired data Lecturers:Dr. Wei-Chung Liu

12/17(Thu) Nonparametric Statistics (II) (1)Kruskal-Wallis test (2)Randomization/permutation test for two-way ANOVA (3)The product-moment correlation coefficient (4)Spearman rank correlation (5)Kendall’s coefficient of rank correlation Lecturers:Dr. Wei-Chung Liu

12/24(Thu) Review Week (no class)

12/31(Thu) Final Exam