風險評估數學模擬
Mathematical Modeling for Risk Assessment
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 風險評估數學模擬 YL403（陽明） 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
Course Objective The major objective is to provide students with a basic understanding of the principles of statistical and mathematical modeling, including benchmark dose (BMD), probabilistic analysis (Monte Carlo simulation), pharmacokinetics (PK)/toxicokinetics (TK), pharmacodynamics (PD)/toxicodynamics (TD), and physiologically based pharmacokinetic (PBPK). Also, to promote students to understand how these models/methods are applied in risk assessment. Course Description Through teaching and practical exercises, students will discover how mathematical concepts help us conduct the various components of health risk assessment and understand the applications of mathematical modeling to various study sciences, including toxicology, human health, and pharmacology.
Risk assessment and toxicology
無備註
教師未提供此項資料
1. Class participation and performance (30%) 2. Class practices (40%) 3. Final presentation (30%)
教師未提供此項資料
| 週次 | 主題 |
|---|---|
| 第 1 週 | Course introduction 2022/9/12 |
| 第 2 週 | Introduction to benchmark dose (BMD) model 2022/9/19 |
| 第 3 週 | BMD model practices (I) 2022/9/26 |
| 第 4 週 | BMD model practices (II) 2022/10/3 |
| 第 5 週 | BMD model practices (III) 2022/10/10 |
| 第 6 週 | Introduction to probabilistic risk assessment (PRA) 2022/10/17 |
| 第 7 週 | PRA practices (I) 2022/10/24 |
| 第 8 週 | Midterm exam 2022/10/31 |
| 第 9 週 | PRA practices (II) 2022/11/7 |
| 第 10 週 | Introduction to pharmacokinetics (PK) modeling (I) 2022/11/14 |
| 第 11 週 | Introduction to PK modeling (II) 2022/11/21 |
| 第 12 週 | Introduction to physiologically based pharmacokinetic (PBPK) modeling (I) 2022/11/28 |
| 第 13 週 | Introduction to PBPK modeling (II) 2022/12/5 |
| 第 14 週 | PBPK practices (I) 2022/12/12 |
| 第 15 週 | PBPK practices (II) 2022/12/19 |
| 第 16 週 | Final exam 2022/12/26 |
| 第 17 週 | Course review 2023/1/2 |
| 第 18 週 | Course review 2023/1/9 |
1. Spruill WJ, Wade WE, DiPiro JT, Blouin RA, Pruemer JM. 2014. Concepts in Clinical Pharmacokinetics (6th edition). Bethesda, MD: American Society of Health-System Pharmacists. 2. Shargel L, Yu ABC. 2015. Applied Biopharmaceutics & Pharmacokinetics (7th edition). Singapore: McGraw-Hill Education. 3. Hayes AW, Kruger CL. 2014. Hayes’ Principles and Methods of Toxicology (6th edition). Boca Raton, FL: CRC Press. 4. Reddy MB, Yang RSH, Clewell HJ III, Andersen ME. 2005. Physiologically Based Pharmacokinetic Modeling: Science and Applications (1st edition). Hoboken, NJ: John Wiley & Sons, Inc. 5. Fisher JW, Gearhart JM, Lin Z. 2020. Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk (1st edition). Cambridge, MA: Academic Press.
- 地點
- 教師未提供此項資料
- 時間
- 教師未提供此項資料
- 聯絡方式
- 教師未提供此項資料