老化生物學:基礎概論與轉譯醫學
The Biology of Aging : Concepts and Translational Medicine
| 節 | 週二 |
|---|---|
7 15:30–16:20 | 老化生物學:基礎概論與轉譯醫學 YK533（陽明） 2 節連堂 |
8 16:30–17:20 |
* 根據陽明交大上課時間表所列
As human life span progressively increases worldwide, knowledge of the effects of aging on human pathophysiology has become of great relevance to medicine. Therefore, developing strategies to maintain optimal health and to promote healthy aging in an increasingly aging human population is becoming a global challenge and an urgent need. This course aims to provide an overview of the fundamental concepts in modern gerontology, namely the biology of aging, and to review the latest and most important advances and themes in translational medicine. The course will cover the following parts: Part-I, basic mechanisms and pathways that associate with aging and longevity; Part-II, interventions that modulate aging and prolong healthspan in mammals; Part-III, Human genetics in aging and longevity.
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(1) Written reports on thematic topics (70%) (2) Oral presentation and written report on that presentation (30%)
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| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction: An overview of the biology of aging 2024-02-20(二) 時數：[2024-02-20]蔡亭芬(2.00) |
| 第 2 週 | Hallmarks of aging: DNA damage and repair 2024-02-27(二) 時數：[2024-02-27]蔡亭芬(2.00) |
| 第 3 週 | Hallmarks of aging: Mitochondrial DNA and functions 2024-03-05(二) 時數：[2024-03-05]蔡亭芬(2.00) |
| 第 4 週 | Hallmarks of aging: Deregulated nutrient- sensing (Sirtuins, mTOR and AMPK) 2024-03-12(二) 時數：[2024-03-12]蔡亭芬(2.00) |
| 第 5 週 | Hallmarks of aging: Cellular senescence, SASP and beyond 2024-03-19(二) 時數：[2024-03-19]蔡亭芬(2.00) |
| 第 6 週 | Written report & Panel discussion-I 2024-03-26(二) 時數：[2024-03-26]蔡亭芬(2.00) |
| 第 7 週 | Hallmarks of aging: Dysbiosis 2024-04-02(二) 時數：[2024-04-02]蔡亭芬(2.00) |
| 第 8 週 | Biomarkers of aging: Evaluation of anti-aging and longevity interventions 2024-04-09(二) 時數：[2024-04-09]蔡亭芬(2.00) |
| 第 9 週 | Intervention: Dietary restriction and intermittent fasting 2024-04-16(二) 時數：[2024-04-16]蔡亭芬(2.00) |
| 第 10 週 | Oral presentation & Panel discussion-II 2024-04-23(二) 時數：[2024-04-23]蔡亭芬(2.00) |
| 第 11 週 | Intervention: Targeting Sirtuins and AMPK 2024-04-30(二) 時數：[2024-04-30]蔡亭芬(2.00) |
| 第 12 週 | Intervention: Targeting mTOR and senotherapeutics 2024-05-07(二) 時數：[2024-05-07]蔡亭芬(2.00) |
| 第 13 週 | Oral presentation & Panel discussion-III 2024-05-14(二) 時數：[2024-05-14]蔡亭芬(2.00) |
| 第 14 週 | Intervention: Exercise and mimetics 2024-05-21(二) 時數：[2024-05-21]蔡亭芬(2.00) |
| 第 15 週 | Hallmarks of aging & Intervention: Inflammaging and Autophagy 2024-05-28(二) 時數：[2024-05-28]蔡亭芬(2.00) |
| 第 16 週 | Oral presentation & Panel discussion-IV 2024-06-04(二) 時數：[2024-06-04]蔡亭芬(2.00) |
(1) Handbook of the Biology of Aging (ScienceDirect, 9th Edition, 2021; Nicolas Musi and Peter Hornsby) (2) Handouts: Review and research articles
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