質譜數據解析與生醫科技應用

Mass Spectrometry Data Analysis and Applications in Biomedicine and Biotechnology

學期

114-2

學分

3 學分

當期課號

430038

永久課號

BTBT30203

開課單位

生物資訊及系統生物研究所、生物科技學系、分子醫學與生物工程研究所、工程生物科學學院產業博士班、生醫科學與工程博士學位學程、跨領域神經科學博士學位學程

授課教師

陳誼如

校區

博愛

類別

選修

上課時間表

節	週五
5 13:20–14:10	質譜數據解析與生醫科技應用 BI301（博愛） 3 節連堂
6 14:20–15:10
7 15:30–16:20

* 根據陽明交大上課時間表所列

概述

This course introduces students to the fundamental principles of mass spectrometry and its integration with modern omics technologies. Students will explore how these techniques are applied at the intersection of biomedicine and biotechnology to address complex biological questions, advance clinical applications, support drug development, and enable physiological and metabolic analysis. The course provides a comprehensive overview of how mass spectrometry can be applied to diverse biological samples and clinical specimens, highlighting its role in proteomics, PTMomics, biomarker discovery, immunology, signaling pathways, and multi-omics. In addition to lectures, students will engage in hands-on projects that involve analyzing real mass spectrometry datasets, gaining practical skills in data interpretation and application. By the end of the course, students will have developed a solid foundation in mass spectrometry analysis and will be equipped to apply these approaches in research across the fields of biomedicine and biotechnology. *** Please bring your own laptop to the course for the hand-on practice.

先修科目

Basic concepts or knowledge of biochemistry, analytical chemistry, or cell biology Basic skills for using excel or programming

備註

無備註

教學方式

Lectures, PowerPoint presentation, self-edited teaching materials, discussion, and hand-on practice

評分方式

Project assignment (30%) + Presentation (30%) + Final report (20%) Quizzes, class interaction, Q&A (20%)

課程大綱

教師未提供此項資料

週次計畫

週次	主題
第 1 週	National Holiday (no class) 時數：[2026-02-27]陳誼如(3.00)
第 2 週	Course introduction Concept of mass spectrometry (MS)-based omics 時數：[2026-03-06]陳誼如(3.00)
第 3 週	Principals and technology of mass spectrometry (MS)-based omic analysis 時數：[2026-03-13]陳誼如(3.00)
第 4 週	(1) Biomarker discovery by shotgun proteomics (2) Project-based study and hand-on practice 時數：[2026-03-20]陳誼如(3.00)
第 5 週	(1) Label-free quantitative proteomics (2) Project-based study and hand-on practice 時數：[2026-03-27]陳誼如(3.00)
第 6 週	National Holiday (no class) 時數：[2026-04-03]陳誼如(3.00)
第 7 週	(1) Isobaric labeling quantitation of tissue proteomics (2) Project-based study and hand-on practice 時數：[2026-04-10]陳誼如(3.00)
第 8 週	(1) Quantitative phosphoproteomics (2) Project-based study and hand-on practice 時數：[2026-04-17]陳誼如(3.00)
第 9 週	(1) MS-based (immuno-)peptidomics (2) Project-based study and hand-on practice 時數：[2026-04-24]陳誼如(3.00)
第 10 週	National Holiday (no class) 時數：[2026-05-01]陳誼如(3.00)
第 11 週	(1) Large-scale plasma proteomics in patients (2) Project-based study and hand-on practice 時數：[2026-05-08]陳誼如(3.00)
第 12 週	(1) Multi-omics in patients (2) Project-based study and hand-on practice 時數：[2026-05-15]陳誼如(3.00)
第 13 週	Project-based study and oral presentation (1) 時數：[2026-05-22]陳誼如(3.00)
第 14 週	Project-based study and oral presentation (2) 時數：[2026-05-29]陳誼如(3.00)
第 15 週	Project-based study and oral presentation (3) (Self-study / Prof. Chen will attend an international conference) 時數：[2026-06-05]陳誼如(3.00)
第 16 週	Final competition – final report and independent testing 時數：[2026-06-12]陳誼如(3.00)

教科書

(1) Advances in Omics Technologies: Exploring Genomics, Proteomics, and Metabolomics, eBook, 2025 (2) From Proteins to Proteomics: Basic Concepts, Techniques, and Applications (By Sanjeeva Srivastava, Published December 28, 2022 by CRC Press) (3) Mass Spectrometry Handbook (Mike S. Lee), 2012 (4) Published literature and reviews (5) Self-edited teaching materials

Office Hours

地點: Room 520, BioICT Building, Boai Campus (博愛校區賢齊館520)
時間: Arrange time by Email
聯絡方式: tp7249@nycu.edu.tw