離子通道與膜電生理概論
Introduction of ion channels and membrane electrophysiology
| 節 | 週四 |
|---|---|
N 12:20–13:10 | 離子通道與膜電生理概論 YR102（陽明） |
* 根據陽明交大上課時間表所列
本課程的內容包含離子通道電生理及其調控機制，細胞膜電位及離子通透原理。同時也會介紹離子通道的結構，如何篩選特定離子通過，離子通道在神經及心臟系統的功能及相關疾病。This course covers selected topics of ion channel biophysics for students with a major interest in membrane physiology. Topics to be covered include membrane potential, voltage-dependent channel gating, ion channel blockers, ion permeation through channel pores, structure/function relationships of ion channels and cell biology of ion channels. The role of ion channels in neurology and cardiology and relevant channelopathies will be introduced as well.
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無備註
本課程的目標是瞭解細胞膜電生理學，離子通道功能及相關研究之方法學 The goal of this course is to understand membrane biophysics, gating of ion channels and recent advances in the methodology of ion channel related studies.
課程參與40%，第一次期中考20%，第二次期中考20%，期末考20% Attendance and in-class performance 40%,1st mid-term exam 20%, 2nd mid-term exam 20%, final exam 20%
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| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction of basic membrane physiology I: Diffusion, Chemical equilibrium, Protein Biochemistry, and Electricity Primer. 2026-09-10(四) 時數：[2026-09-10]季康揚(1.00) |
| 第 2 週 | Introduction of basic membrane physiology II: Diffusion, Chemical equilibrium, Protein Biochemistry, and Electricity Primer. 2026-09-17(四) 時數：[2026-09-17]季康揚(1.00) |
| 第 3 週 | Resting Membrane Potential I: Nernst Equation, Goldman-Hodgkin-Katz Equation 2026-09-24(四) 時數：[2026-09-24]季康揚(1.00) |
| 第 4 週 | Resting Membrane Potential II: Nernst Equation, Goldman-Hodgkin-Katz Equation 2026-10-01(四) 時數：[2026-10-01]季康揚(1.00) |
| 第 5 週 | First exam 2026-10-08(四) 時數：[2026-10-08]季康揚(1.00) |
| 第 6 週 | Ion Permeations I: Long Pore Effect, Ion Binding and Saturation, Ion Selectivity, Multi-Ion Occupancy. 2026-10-15(四) 時數：[2026-10-15]季康揚(1.00) |
| 第 7 週 | Ion Permeations II: Long Pore Effect, Ion Binding and Saturation, Ion Selectivity, Multi-Ion Occupancy. 2026-10-22(四) 時數：[2026-10-22]季康揚(1.00) |
| 第 8 週 | Channel Blockers: Woodhull Model, Channel Structure and Function Implied from Blocker Actions 2026-10-29(四) 時數：[2026-10-29]季康揚(1.00) |
| 第 9 週 | 2nd exam 2026-11-05(四) 時數：[2026-11-05]季康揚(1.00) |
| 第 10 週 | Voltage-Dependent Mechanism: Voltage Dependence, Gating Charge, and Voltage Sensor 2026-11-12(四) 時數：[2026-11-12]季康揚(1.00) |
| 第 11 週 | Methodology of studying ion channels I: basic concepts of patch clamp technique and its applications 2026-11-19(四) 時數：[2026-11-19]季康揚(1.00) |
| 第 12 週 | Methodology of studying ion channels II: interpretation of results from patch clamp studies 2026-11-26(四) 時數：[2026-11-26]季康揚(1.00) |
| 第 13 週 | Application of ion channel studies in neurology: introduction of channelopathy in neurology and pharmacological application 2026-12-03(四) 時數：[2026-12-03]季康揚(1.00) |
| 第 14 週 | Application of ion channel studies in pulmonary: introduction of channelopathy in neurology and pharmacological application 2026-12-10(四) 時數：[2026-12-10]季康揚(1.00) |
| 第 15 週 | Application of ion channel studies in cardiology: introduction of channelopathy in cariology and pharmacological application 2026-12-17(四) 時數：[2026-12-17]季康揚(1.00) |
| 第 16 週 | Final exam 2026-12-24(四) 時數：[2026-12-24]季康揚(1.00) |
Hille, B. (2001) Ion Channels of Excitable Membranes, 3rd Ed. Sinauer Associates, Inc. Sunderland, MA, USA.
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