生醫類器官
Biomedical Organoids
| 節 | 週四 |
|---|---|
6 14:20–15:10 | 生醫類器官 BI301（博愛） 3 節連堂 |
7 15:30–16:20 | |
8 16:30–17:20 |
* 根據陽明交大上課時間表所列
The emerging needs for discovering and developing successful treatments for cancer and degenerative disease, either inherited or spontaneously occurred, are devastating. These are currently unmet medical needs. Organoids are newly developed biomedical system of patient-in-a-test-tube which highly represents patients’ pathological signatures in multiple ways including genetic heterogeneities, cellular behavior, disease progressions, drug response, and organizations of a tissue in vivo. Organoids can be derived from biopsies of tumor patients directly or by a stepwise differentiation procedures for generating mini-tissues from induced pluripotent stem cells (iPSCs) of same patient. These advancing breakthroughs pave new ways in biomedical research. It becomes feasible of using in vitro or ex vivo system as a replacements of real human subjects and it accelerates biomedical discoveries with high accuracies in terms of translation medicine. In this course, we present an introduction of biomedical organoids in both cancer organoids and organoids derived from iPSCs as model system and bring the knowledges of biomedical organoids from established disease model system of the frontiers of challenging biomedical research including anti-tumor therapies and treatments for degenerative diseases for students. We present these from bedside-to-bench and bench-to-bedside discoveries of using biomedical organoids as model systems in a main theme of stating from basic science and to the potential biomedical applications. This course is a combination of the research coalition inputs from Bo-Ai campus and Yang Ming campus of National Yang Ming Chiao Tung University. And we hope to inspire and ignite new comers who are brave enough aiming to find the answers for these currently unmet medical needs.
his course is a multidisciplinary course combing molecular biology, oncology, stem cell biology and gene therapies. Students who are interested in oncology and stem cell biology can join this course.
無備註
提供上課講義與參考資料
平時成績 面授出席率 5% 課堂點名 議題發言 5% 學生主動參與度 議題回應 5% 學生對於課程主題的了解度 作業 25% 13次 (例)課堂作業0次、課後作13次 期中考/報告 30% 1次 期中報告 期末考/報告 30% 2次 期末報告 合計 100%
教師未提供此項資料
| 週次 | 主題 |
|---|---|
| 第 1 週 | Cancer Organoids are incarnations of cancer stem cell hypothesis (邱光裕) |
| 第 2 週 | Methods for establishing cancer organoids – War on Cancer 2.0 (邱光裕) |
| 第 3 週 | Gene editing in cancer organoids – Synthetic biology in cancer organoids (邱光裕) |
| 第 4 週 | Precision and personalized medicine in cancer organoids – Unlocking gene-drug associations (邱光裕) |
| 第 5 週 | Cell based immunotherapies derived from cancer organoids – A novel system for adoptive cell therapy (ACT) (邱光裕) |
| 第 6 週 | Lineage tracing of dynamics of tumor traits in cancer organoids (邱光裕) |
| 第 7 週 | Bio-engineering of defined extracellular matrix (ECM)/scaffolds for cancer organoids (邱光裕) |
| 第 8 週 | Summaries and discussions of cancer organoids (邱光裕) |
| 第 9 週 | What is stem cells? (周士傑) |
| 第 10 週 | Organoids and mini-organs (周士傑) |
| 第 11 週 | Pluripotent stem cell derived lung organoids (周士傑) |
| 第 12 週 | Pluripotent stem cell derived retinal organoids (周士傑) |
| 第 13 週 | Pluripotent stem cell derived cardiovascular organoids (周士傑) |
| 第 14 週 | Pluripotent stem cell derived liver-associated organoids (周士傑) |
| 第 15 週 | Class discussion Ⅰ (周士傑) |
| 第 16 週 | Class discussion Ⅱ (周士傑) |
教科書： Organoids and Mini-Organs 作者/創建者 Davies, Jamie A., editor. Lawrence, Melanie L., editor. 識別號 ISBN : 9780128126370 (electronic bk.) ISBN : 012812637X (electronic bk.) ISBN : 9780128126363 ISBN : 0128126361 OCLC : (OCoLC)1028979397 Organoids Stem Cells, Structure, and Function 作者/創建者 Turksen, Kursad. editor. 識別號 ISBN : 1-4939-7617-6 OCLC : (OCoLC)1122912802 ISBN : 1-4939-7616-8
- 地點
- 賢齊館R627 北榮致德樓幹細胞實驗室
- 時間
- 預約
- 聯絡方式
- 授課教師：邱光裕：chiougy@nycu.edu.tw, 周士傑：sjchou@nycu.edu.tw