高等有機化學(一)

The course’s emphasis is on orbital interactions in structure and reactivity. It will occasionally refer to Stereoelectronic Effects, Wiley, 2016. The whole course will be taught using the materials prepared by the teacher while referring to the text book.

The course covers organic structure, bonding and mechanisms. It will be taught along the text book Advanced Organic Chemistry, F. A. Carey and R. J. Sundberg 4th Edition, 2000, Part A, but its 5th Edition, 2007 will also be used where appropriate.

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There will be occasional exercises to the confirm students’ understanding, which will be counted as attendance. The final score will be the sum of the scores of the mid-term and final exams plus the exercises.

• Chemical Bonding and Molecular Structure

  Valence Bond Theory and Molecular Orbital Theory The Hückel MO Method and its Application Perturbation in MOs and Frontier MOs Electron Density Functional Method Electron Density Distribution Hyperconjugation

• Principles of Stereochemistry: Configuration and Conformation

  Configuration Stereochemistry Conformation and Conformation Analysis Separation of Enantiomers

• Steric and Stereoelectronic Effects

  Strain Molecular Mechanics Calculations Stereoelectronic Effect Anomeric Effect

• Study and Description of Organic Reaction Mechanisms

  General Relationships between Thermodynamic Stability and Reaction Rates Kinetic Isotope Effect Linear Free-Energy Relationships for Substituent Effects Solvent Effect

• Nucleophilic Substitutions

  Mechanistic Limiting Cases and Borderline Cases Carbocations Nucleophilicity, Effects of Leving Groups and Solvents Steric and Strain Effects on Substitution and Ionization Effects of Conjugation Stereochemistry of Nucleophilic Substitution Neighboring Group Participation

• Aromaticity

  Criteria of Aromaticity Examples of Aromatic and Antiaromatic Molecules Various Types of Aromaticity

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地點

科學二館201教室

時間

T567

聯絡方式

by email: tobe@nycu.edu.tw