奈米電子生醫感測
NanoDevices in Biosensing
| 節 | 週五 |
|---|---|
5 13:20–14:10 | 奈米電子生醫感測 A305（光復） 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
With the achievements of nanotechnology and nanoscience, a wide variety of nanoscale materials and devices with different sizes (1–100 nm), shapes, and compositions have been introduced to biosensing. The small sizes of nanoparticles and nanodevices break through the limitation of structure miniaturization, leading to a lower detection limit, even reaching zeptomolar concentrations. Based on fundamentals of theories, aside from optical biosensing, this course introduces and emphysizes novel principles and detection strategies in biosensing for nanomaterials and nanodevices. Each topic provides a theoretical overview of different topics like potentialmetric, amperometric and cantilever-based nanosings, and the correspondent interesting bioanalytical applications. The most exciting and unique aspect of this course is that the utilization of nanomaterials and nanodevices not only enhances the biosensing capabilities, but also brings out newer approaches such as reagent-less biosensing, label-free biosensing, and single molecular detection.
近代物理或物理(Modern Physics or Physics),基礎化學(Chemistry), 基礎生物(Biology),半導體元件物理(Semiconductor device physics)
無備註
Slides in ppt extracted from books and research articvles will be provided weekly based on each topic.
(1) Midterm#1 Exam 25% (2) Midterm#2 Exam 25% (3) Final Exam 25% (3) Home works 25%
教師未提供此項資料
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction to nanobiosensors - Why nanobiosensing - Types of nanobiosensors - Basic Concepts: Biomolecules, Analyte Density, Diffusion Distances - Basic Concepts: Geometry effects in nanoBiosensing |
| 第 2 週 | How the target molecules diffuse onto the surface of nanobiosensors: dimensionality factor |
| 第 3 週 | Holidy |
| 第 4 週 | Silicon NanoFETs as biosensors - Why nanoFETs instead of MOSFETs? - Electrical models in biosensing - Limitations of NanoFETs as biosensors - beyond nanoFETs |
| 第 5 週 | Geometry effects on nanobiosensors - settling time- Shape of sensor surface - Sensors with Complex Geometry - Beating the diffusion limits -- Droplet Evaporation |
| 第 6 週 | Exam#1: one hour Geometry effect on nanobiosensors - Beating the Diffusion Limit: -- Enhanced Diffusion with micro Fluid Flow - Passage and Escape Time of a cell |
| 第 7 週 | Sensitivity - Nanobiosensors Sensitivity and Types of Biosensors- Potentiometric Sensors: Charge Screening for a Planar Sensor - Potentiometric Sensors: Charge Screening |
| 第 8 週 | Semiconductor Nanowire Sensors - Potentiometric Sensors: ISFET as a pH-Meter - Potentiometric Sensors: Why are Biomolecules Charged? - Debye screening length in liquid and semiconductors |
| 第 9 週 | Sensitivity - Amperometric Sensors - Glucose Sensor - Amperometric Sensors: Beating the Diffusion Limit by Nanogap Amperometry - Cantilever-based Sensors - Noises etc. |
| 第 10 週 | Exam#2: one hour Sensitivity - Amperometric Sensors - Glucose Sensor I Sensitivity - Amperometric Sensors: Glucose Sensors II |
| 第 11 週 | Sensitivity - Amperometric Sensors: Beating the Diffusion: Limit by Nanogap Amperometry |
| 第 12 週 | Sensitivity - Cantilever-based Sensors: Basic Operation Sensitivity - Cantilever-based Sensors: Static Response Sensitivity - Cantilever-based Sensors: Nonlinear Sensing - Flexure FET |
| 第 13 週 | Selectivity and system considerations - Introduction and Molecular Recognition - from sensor to circuits and system - Tag, filer and amplify |
| 第 14 週 | Selectivity - Introduction and Molecular Recognition Selectivity - Physics of Sequential Adsorption Selectivity - When all else fails, tag, filer and amplify Selectivity - Noise in nanoMOSFET Selectivity - Anti-fouling to avoid non-specific binding |
| 第 15 週 | Case study with NanoFETs for DNA sequencing: - Putting the Pieces Together - Genome Sequencer I - Putting the Pieces Together - Genome Sequencer II - Putting the Pieces Together - Genome Sequencer III - Putting the Pieces Together - Concluding Thoughts |
| 第 16 週 | Final exam |
References 1) NanoBiosensing, Principles, Development and Application, ISBN 978-1-4419-9621-3, 2011 2) NanoBiosensing, ISBN 978-1-4419-6168-6, 2011 3) Nanobiosensors: From Design to Applications, Editor(s):Aiguo Wu, Waheed S. Khan, 2020 4) Research articles
- 地點
- 田家炳616A
- 時間
- Monday 15:00~16:00 and Wednesday 13:30 ~14:30
- 聯絡方式
- ~31491 or sheujt@nycu.edu.tw